merck millipore,默克密理愽
  • merck millipore,默克密理博,435930,LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem

  • merck millipore,默克密理博,435930,LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem

    产品名称：LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem
    产品型号：435930
    The LIM Kinase Inhibitor I, LIMKi 3 controls the biological activity of LIM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,435930,LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,435930,LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₄Cl₂F₂N₄OS
    描述
    概述 A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1 µM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10 µM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10 µM) with concomitant blockage of invasion (by 93% at 10 µM).
    产品目录编号 435930
    品牌系列 Calbiochem®
    同义词 N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide
    参考
    参考 Scott, R.W., et al. 2010. J. Cell. Biol. 191, 169.
    Ross-Macdonald, P., et al. 2008. Mol. Cancer Ther. 7, 3490.
    产品信息
    形式 Beige powder
    Hill配方 C₁₇H₁₄Cl₂F₂N₄OS
    Molar Mass 431.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 LIMK1 and LIMK2
    主靶IC50 7 and 8 nM against LIMK1 and LIMK2, respectively
    副靶 AMPKA1, AMPKA2, DDR1, PAK3, DCAMKL2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,435930,LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,124039,InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,LSKNS0500,中和溶液，0.5 L


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