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merck millipore,默克密理博,AB1846,Anti-C-X-C Chemokine Receptor 4 Antibody, NT
产品名称：Anti-C-X-C Chemokine Receptor 4 Antibody, NT
产品型号：AB1846
Anti-C-X-C Chemokine Receptor 4 Antibody, N-terminus is an antibody against C-X-C Chemokine Receptor 4 for use in IC, IP & WB.
merck millipore,默克密理博,AB1846,Anti-C-X-C Chemokine Receptor 4 Antibody, NT
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 AB1846 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-C-X-C Chemokine Receptor 4 Antibody, NT Alternate Names - CXCR4
- CD184
产品信息 格式 Purified 控制 - Skin
演示 Purified IgG in PBS containing 0.02% sodium azide. 应用 应用 Anti-C-X-C Chemokine Receptor 4 Antibody, N-terminus is an antibody against C-X-C Chemokine Receptor 4 for use in IC, IP & WB. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1-2 μg/mL. HeLa cell lysates can be used as positive control. The antibody should detect a band at 40 kDa.
Immunocytochemistry: 10 μg/mL
Immunoprecipitation
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Amino-terminus peptide of human CXCR4 (Berson, 1996; Leotscher, 1994). 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes CXCR4, N-terminus. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003467.2
- NM_001008540.1
Entrez基因汇总 This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. 基因符号 - LESTR
- CXCR4
- WHIM
- NPY3R
- NPYY3R
- FB22
- LAP3
- Fusin
- CXCR-4
- LCR1
- NPYR
- HM89
- fusin
- HSY3RR
- CXC-R4
- NPYY3
- NPYRL
- D2S201E
- CD184
纯化方法 Protein A purfied UniProt编号 - P61073
UniProt汇总 FUNCTION: SwissProt: P61073 # Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
SIZE: 352 amino acids; 39746 Da
SUBUNIT: Interacts with HIV-1 surface protein gp120 and Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
DOMAIN: SwissProt: P61073 The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.
PTM: Sulfated.
DISEASE: SwissProt: P61073 # Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain 1 year at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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