merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1365,Anti-SRp40 Antibody

  • merck millipore,默克密理博,06-1365,Anti-SRp40 Antibody

    产品名称：Anti-SRp40 Antibody
    产品型号：06-1365
    Use Anti-SRp40 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect SRp40 also known as serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40.

    merck millipore,默克密理博,06-1365,Anti-SRp40 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1365,Anti-SRp40 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1365
    描述 Anti-SRp40 Antibody
    Alternate Names
    • splicing factor, arginine/serine-rich 5
    • serine/arginine-rich splicing factor 5
    • Pre-mRNA-splicing factor SRP40
    • Delayed-early protein HRS
    • SR splicing factor 5
    背景信息 SRp40 is a nuclear phosphoprotein that is a member of the SR family of proteins. Essential for alternative splicing regulation this protein is also known as Serine/arginine-rich splicing factor 5, and Delayed-early protein HRS. The SRp40 protein is a component of the spliceosome complex and appears to play a role in splice site selection. Over-expression of SRp40 is thought to cause increased chondrogenic differentiation of mesenchymal cells. In addition, increased expression of SRp40 has been found in breast tumor tissues and is associated with alternative pre-mRNA splicing of CD44.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-SRp40 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect SRp40 also known as serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis:
    A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
    生物信息
    免疫原品种 Linear peptide corresponding to human SRp40.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001034554
    Entrez基因汇总 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
    基因符号
    • SFRS5
    • SRP40
    • SRSF5
    • HRS
    纯化方法 Protein A
    UniProt编号
    • Q13243
    UniProt汇总 FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

    SUBUNIT STRUCTURE: Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.

    SUBCELLULAR LOCATION: Nucleus.

    PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

    Contains 2 RRM (RNA recognition motif) domains.

    SEQUENCE CAUTION: The sequence AAC39543.1 differs from that shown. Reason: Frameshift at positions 113 and 140.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 1:500 dilution of this antibody detected SRp40 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,06-1365,Anti-SRp40 Antibody

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