merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN20,Anti-Dopamine D(1A) Receptor Antibody

  • merck millipore,默克密理博,ABN20,Anti-Dopamine D(1A) Receptor Antibody

    产品名称：Anti-Dopamine D(1A) Receptor Antibody
    产品型号：ABN20
    Anti-Dopamine D(1A) Receptor Antibody detects level of Dopamine D(1A) Receptor & has been published & validated for use in IH, WB, ELISA.

    merck millipore,默克密理博,ABN20,Anti-Dopamine D(1A) Receptor Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN20,Anti-Dopamine D(1A) Receptor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    B, RELISA, IHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN20
    Replaces AB1765P;
    描述 Anti-Dopamine D(1A) Receptor Antibody
    Alternate Names
    • dopamine receptor D1, D(1A) dopamine receptor
    背景信息 Dopaminergic signals are thought to modulate corticostriatal synapses onto medium spiny projection neurons, and this plasticity is, in turn, thought to alter patterns of activity during learning. Subversion of these processes in clinical and rodent models is hypothesized to contribute importantly to addiction to psychostimulants, seizures, and movement disorders in Huntington’s (HD) and Parkinson’s disease (PD). Dopamine receptor D1, also known as DRD1, is the most abundant dopamine receptor (of the five types D1-D5) in the central nervous system and is critically involved in these processes and the modulation of D2 receptor mediated events. Coupled with G-protein, the D1a receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases including the key molecular switch, DARPP-32.
    产品信息
    格式 Affinity Purified
    控制
    • Rat testis tissue lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Dopamine D(1A) Receptor Antibody detects level of Dopamine D(1A) Receptor & has been published & validated for use in IH, WB, ELISA.
    主要应用
    • ELISA
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected D(1A) dopamine receptor in rat brain tissue.

    ELISA Analysis: Tested in ELISA against antigen-coated plate. A 1:100 dilution from a previous lot detected dopamine D(1A) receptor peptide.
    生物信息
    免疫原品种 KLH-conjugated linear peptide of rat dopamine D(1A) receptor at and around the cytoplasmic domain.
    表位 Cytoplasmic Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes D(1A) dopamine receptor.
    品种反应性 BovineRat
    Species Reactivity Note Demonstrated to react with rat. Predicted to react with bovine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_036678
    Entrez基因汇总 Induces dopamine sensitive adenylate cyclase activation; plays a role in regulating food intake [RGD].
    基因符号
    • Drd1a
    • D1a
    • Drd1
    • Drd-1
    纯化方法 Affinity Purfied
    UniProt编号
    • P18901
    UniProt汇总 FUNCTION: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    SUBUNIT STRUCTURE: Interacts with calcyon By similarity. Interacts with DNAJC14 via its C-terminus.

    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.

    TISSUE SPECIFICITY: Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.

    PTM: N-glycosylated.

    SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    质量保证 Evaluated by Western Blot in rat testis tissue lysate.

    Western Blot Analysis: 2 µg/ml of this antibody detected dopamine D(1A) receptor in 10 µg of rat testis tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABN20,Anti-Dopamine D(1A) Receptor Antibody

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