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merck millipore,默克密理博,124039,InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
产品名称：InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
产品型号：124039
The InSolution™ Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>
merck millipore,默克密理博,124039,InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₂₅ClN₂O • HCl 925681-41-0 描述 概述 A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available. 产品目录编号 124039 品牌系列 Calbiochem®
同义词 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl 参考 参考 Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.产品信息 CAS号 925681-41-0 形式 Liquid 配方 A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O. Hill配方 C₂₀H₂₅ClN₂O • HCl 化学配方 C₂₀H₂₅ClN₂O • HCl Molar Mass 381.4 可逆 Y 结构配方图像 生物信息 主靶 Akt 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避光 Protect from light
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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