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品种反应性 主要应用 宿主 格式 抗体类型 H IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB4336 Replaces MAB433 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MDR1 Antibody, clone 5A12.2 Alternate Names - Pgp
- P-glycoprotein
- CD243
- p170
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.02M PBS pH 7.6, 0.25M NaCl with 0.1% sodium azide. 应用 应用 This Anti-MDR1 Antibody, clone 5A12.2 is validated for use in IH, IH(P) for the detection of MDR1. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry on frozen and paraffin embedded tissue sections: 1:40.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Human MDR-transfected NIH3T3 cells 克隆 5A12.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 5A12.2 recognizes human P-glycoprotein encoded by the MDR1 (ABCB1) gene, a member of the ABC superfamily of ATP-binding cassette transporters. Expression of P-glycoprotein is associated with ATP-dependent transmembrane efflux of chemically diverse compounds from the cell and is the major component of multidrug resistance in human tumors. 同种型 IgG2b 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000927.3
Entrez基因汇总 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. 基因符号 - EC 3.6.3.44
- ABCB1
- PGY1
- MGC163296
- CD243
- GP170
- P-gp
- MDR1
- CLCS
- ABC20
UniProt编号 - P08183
UniProt汇总 FUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
SIZE: 1280 amino acids; 141463 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 100 µg
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