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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-624 品牌系列 Upstate
商名 - Upstate
描述 Anti-hSNF2H Antibody 概述 The SNF2 family of proteins are ATP dependant chromatin remodeling enzymes. The gene encoding this protein is also known as SMARCA5 产品信息 格式 Affinity Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect hSNF2H with Anti-hSNF2H Antibody (Rabbit Polyclonal Antibody), that has been shown to work in ChIP, IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 58-77 (MEEIFDDASPGKQKEIQEPD) of human hSNF2H (SWI/SNF-related matrix-associated actin-dependent chromatin a5) 宿主 Rabbit 特异性 hSNF2H 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因汇总 The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. 基因符号 - ISWI
- SMARCA5
- WCRF135
- hISWI
- hSNF2H
- SNF2H
- HSNF2H
纯化方法 Immunoaffinity purified UniProt编号 - O60264
UniProt汇总 FUNCTION: SwissProt: O60264 # Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin in vitro; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter.
SIZE: 1052 amino acids; 121905 Da
SUBUNIT: Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains RSF1; WICH contains BAZ1B. SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A and of SMARCA5/cohesin/NuRD complexes. The BAZ2A subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed.DEVELOPMENTAL STAGE: Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy.
SIMILARITY: SwissProt: O60264 ## Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 2 SANT domains.产品使用声明 质量保证 routinely evaluated by immunoblot in nuclear extracts from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 100 µL
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