merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5416,Anti-Glutamate Receptor 3 Antibody, clone 3B3

  • merck millipore,默克密理博,MAB5416,Anti-Glutamate Receptor 3 Antibody, clone 3B3

    产品名称：Anti-Glutamate Receptor 3 Antibody, clone 3B3
    产品型号：MAB5416
    Anti-Glutamate Receptor 3 Antibody, clone 3B3 is an antibody against Glutamate Receptor 3 for use in WB, IC, IH, IH(P).

    merck millipore,默克密理博,MAB5416,Anti-Glutamate Receptor 3 Antibody, clone 3B3

  • 产品介绍
  • merck millipore,默克密理博,MAB5416,Anti-Glutamate Receptor 3 Antibody, clone 3B3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, H, M, RIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5416
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glutamate Receptor 3 Antibody, clone 3B3
    Alternate Names
    • glutamate receptor, ionotrophic, AMPA 3
    • AMPA-selective glutamate receptor 3
    • Glutamate receptor ionotropic, AMPA 3
    • glutamate receptor 3
    • glutamate receptor C
    • glutamate receptor subunit 3
    • glutamate receptor subunit 3
    • glutamate receptor
    背景信息 AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition.There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. Millipore’s anti-GluR2/3 antibody is useful for localizing expression of GluR2/GluR3 receptor assemblies in the PSD.
    产品信息
    格式 Purified
    控制
    • Hippocampal tissue
    • Brain
    演示 Liquid in PBS. Contains no preservative.
    应用
    应用 Anti-Glutamate Receptor 3 Antibody, clone 3B3 is an antibody against Glutamate Receptor 3 for use in WB, IC, IH, IH(P).
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunohistochemistry: A previous lot of this antibody was used in IH.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Fusion protein, N-terminus of GluR3
    表位 N-terminus
    克隆 clone 3B3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with Glutamate Receptor 3 (GluR3). No cross reactivity with GluR2.
    同种型 IgG1κ
    品种反应性 MonkeyHumanMouseRat
    Species Reactivity Note Human, mouse and monkey. Expected to react with rat based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000840.2
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
    基因符号
    • GRIA3
    • GLUR3
    • GluR3
    • GLURC
    纯化方法 Protein A purfied
    UniProt编号
    • P42263
    UniProt汇总 FUNCTION: SwissProt:P42263 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
    SIZE: 894 amino acids; 101,157 Da
    SUBUNIT:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
    PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
    DISEASE INVOLVEMENT: Defects in GRIA3 are the cause of mental retardation X-linked type 94 (MRX94) [MIM:300699]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia.
    SIMILARITY: SwissProt: P42263 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    产品使用声明
    质量保证 Western Blot Analysis: A previous lot of this antibody was used in WB.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB5416,Anti-Glutamate Receptor 3 Antibody, clone 3B3

上一件merck millipore产品：merck millipore,默克密理博,324864,PhosphoDetect™ Anti-EGFR (pTyr¹¹⁷³) Mouse mAb (9H2)
下一件merck millipore产品：merck millipore,默克密理博,ABN310,Anti-FA2H Antibody


相关产品

merck millipore,默克密理博,AB211-ML-KC,Goat Anti-Rabbit IgG Fc Gamma Fraction (100mL) KC merck millipore,默克密理博,AB211-ML-KC,Goat Anti-Rabbit IgG Fc Gamma Fraction (100mL) KC

merck millipore,默克密理博,523350,PTIO - CAS 18390-00-6 - Calbiochem merck millipore,默克密理博,523350,PTIO - CAS 18390-00-6 - Calbiochem

merck millipore,默克密理博,MAB10424,Anti-Plexin B3 Antibody, clone 17H10.1 merck millipore,默克密理博,MAB10424,Anti-Plexin B3 Antibody, clone 17H10.1

merck millipore,默克密理博,ABT296,Anti-TOMM40 Antibody merck millipore,默克密理博,ABT296,Anti-TOMM40 Antibody

merck millipore,默克密理博,324864,PhosphoDetect™ Anti-EGFR (pTyr¹¹⁷³) Mouse mAb (9H2) merck millipore,默克密理博,324864,PhosphoDetect™ Anti-EGFR (pTyr¹¹⁷³) Mouse mAb (9H2)

merck millipore,默克密理博,ABN310,Anti-FA2H Antibody merck millipore,默克密理博,ABN310,Anti-FA2H Antibody

merck millipore,默克密理博,07-528,Anti-trimethyl (Lys79)-phospho (Thr80)-Histone H3 Antibody merck millipore,默克密理博,07-528,Anti-trimethyl (Lys79)-phospho (Thr80)-Histone H3 Antibody

merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102 merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

merck millipore,默克密理博,HTS039LT,ChemiBrite™ D2L Dopamine Family Receptor Frozen Cells merck millipore,默克密理博,HTS039LT,ChemiBrite™ D2L Dopamine Family Receptor Frozen Cells

merck millipore,默克密理博,324682,Elastase, Porcine Pancreas, High Purity, Crystallized merck millipore,默克密理博,324682,Elastase, Porcine Pancreas, High Purity, Crystallized


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部