merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

  • merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

    产品名称：Anti-phospho-Paxillin (Tyr31) Antibody, clone M102
    产品型号：05-1143
    Detect phospho-Paxillin (Tyr31) using this Anti-phospho-Paxillin (Tyr31) Antibody, clone M102 validated for use in WB.

    merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

  • 产品介绍
  • merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1143
    Replaces MAB1146
    描述 Anti-phospho-Paxillin (Tyr31) Antibody, clone M102
    背景信息 Paxillin is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and an SH3- and SH2-binding domain that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Tyrosine phosphorylation of paxillin occurs in response to growth factors, neuropeptides, and integrins. The major sites of tyrosine phosphorylation include Tyr31 and Tyr118. Both of these sites may be involved in Crk binding to paxillin during integrin-mediated cell adhesion. These sites may provide docking motifs for recruitment of other signaling molecules to focal adhesions.
    产品信息
    格式 Purified
    控制
    • Pervanadate treated L6 cell lysates
    演示 Purified monoclonal IgG1 in phosphate-buffered saline, 50% glycerol, 1 mg/mL BSA, and 0.05% sodium azide.
    应用
    应用 Detect phospho-Paxillin (Tyr31) using this Anti-phospho-Paxillin (Tyr31) Antibody, clone M102 validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Clone M102 was generated from phospho-Paxillin (Tyr31) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 31 of human paxillin. This human sequence is highly conserved in rat and mouse paxillin.
    克隆 M102
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody detects Paxillin phosphorylated at Tyr31.
    同种型 IgG1
    品种反应性 Human
    Species Reactivity Note Reacts with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • P49023
    基因符号
    • paxillin
    • FLJ16691
    修改
    • Phosphorylation
    纯化方法 Protein A chromatography
    UniProt编号
    • P49023
    UniProt汇总 FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
    SUBUNIT STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
    SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
    PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    SEQUENCE SIMILARITIES: Belongs to the paxillin family.
    Contains 4 LIM zinc-binding domains.
    产品使用声明
    质量保证 Evaluated by western Blot in pervanadate treated L6 cell lysates.
    Western Blot Analysis: 1:500 dilution of this lot detected phospho-Paxillin on 10 µg of pervanadate treated L6 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C for one year from date of receipt. Do not aliquot.
    Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-1143,Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

上一件merck millipore产品：merck millipore,默克密理博,07-528,Anti-trimethyl (Lys79)-phospho (Thr80)-Histone H3 Antibody
下一件merck millipore产品：merck millipore,默克密理博,HTS039LT,ChemiBrite™ D2L Dopamine Family Receptor Frozen Cells


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