merck millipore,默克密理愽
  • merck millipore,默克密理博,373275,Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

  • merck millipore,默克密理博,373275,Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

    产品名称：Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem
    产品型号：373275
    The Hh Signaling Antagonist XII, HPI-1, also referenced under CAS 599150-20-6, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applic More>>

    merck millipore,默克密理博,373275,Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373275,Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₇H₂₉NO₆599150-20-6
    描述
    概述 A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 µM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 µM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.
    产品目录编号 373275
    品牌系列 Calbiochem®
    同义词 2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
    参考
    参考 Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.
    产品信息
    CAS号 599150-20-6
    形式 Pale yellow solid
    Hill配方 C₂₇H₂₉NO₆
    化学配方 C₂₇H₂₉NO₆
    Molar Mass 463.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373275,Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

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