merck millipore,默克密理博,MAB5386X,Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488

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merck millipore,默克密理博,MAB5386X,Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488
产品名称：Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488
产品型号：MAB5386X
This Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488 is validated for use in FC, IC for the detection of Nerve Growth Factor Receptor.

merck millipore,默克密理博,MAB5386X,Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488

产品介绍

merck millipore,默克密理博,MAB5386X,Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Sh, H, Po, Rb	ICC, FC	M	AlexaFluor®488	Monoclonal Antibody

描述
产品目录编号	MAB5386X
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488
背景信息	The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells

产品信息
格式	AlexaFluor®488
演示	Liquid. Contains no preservative.

应用
应用	This Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488 is validated for use in FC, IC for the detection of Nerve Growth Factor Receptor.
主要应用	Immunocytochemistry Flow Cytometry
应用说明	Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Human melanoma cell line.
克隆	ME20.4
宿主	Mouse
特异性	Reacts with the low affinity nerve growth factor receptor (NGFR p75). The epitope recognized by the antibody maps within the third or fourth cysteine-rich repeats of the NGFR molecule. Reactivity has not been observed with rat, chicken, or mouse NGFR.
同种型	IgG1
品种反应性	SheepHumanPigRabbit
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002507.2
Entrez基因汇总	Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
基因符号	CD271 NGFR p75(NTR) TNFRSF16 Gp80-LNGFR
非反应性品种	Rat Chicken Mouse
UniProt编号	P08138
UniProt汇总	FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

产品使用声明

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

储存和货运信息
存储条件	Aliquot and store at -20 ºC, or glycerol (ASC grade or better) can be added (1:1) and the antibody stored at -20ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.