- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
描述 产品目录编号 14-314M 品牌系列 Upstate
商名 - Upstate
描述 Syk Protein, active, 250 µg 概述 Recombinant full-length human Syk, containing an N-terminal His6-tag 应用 应用 Active, recombinant full-length human Syk, containing an N-terminal His6-tag, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_003177.3
基因符号 - SYK
蛋白靶 Syk 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - P43405
UniProt汇总 FUNCTION: SwissProt: P43405 # Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion (By similarity).
SIZE: 635 amino acids; 72066 Da
SUBUNIT: Interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL, leading to its destruction. Interacts with phosphorylated NFAM1 (By similarity). Interacts with Epstein-Barr virus LMP2A. Interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation.
PTM: Autophosphorylated. & Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR- stimulated calcium ion signaling (By similarity). & Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3- kinase-independent pathway (By similarity). & Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity).
SIMILARITY: SwissProt: P43405 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.产品使用声明 质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -70C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-314) and in bulk (cat# 14-314-K).
上一件merck millipore产品：merck millipore,默克密理博,AB3585,RABBIT Anti-LIPIN-1 Antibody, NT
下一件merck millipore产品：merck millipore,默克密理博,AB3091,Anti-Aquaporin 9 Antibody
相关产品
merck millipore,默克密理博,AB9303,Anti-Trace Amine Receptor 1 Antibody
merck millipore,默克密理博,MAB5386X,Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488
merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem
merck millipore,默克密理博,AP1167,Anti-TNS4 Mouse mAb (3B8)
merck millipore,默克密理博,AB3585,RABBIT Anti-LIPIN-1 Antibody, NT
merck millipore,默克密理博,AB3091,Anti-Aquaporin 9 Antibody
merck millipore,默克密理博,SLHV033RB,Millex-HV 过滤器，0.45 µm，PVDF，33 mm，可 γ 射线灭菌，已灭菌
merck millipore,默克密理博,487952,NOC-7 - CAS 146724-84-7 - Calbiochem
merck millipore,默克密理博,218773,Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem