merck millipore,默克密理愽
  • merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

  • merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

    产品名称：MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem
    产品型号：475846


    merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₇IN₂41270-96-6
    描述
    概述 A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC50 ~5 vs. 50 µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 µM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 µM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 µM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.) in vivo.
    产品目录编号 475846
    品牌系列 Calbiochem®
    同义词 Macrophage Migration Inhibitory Factor Antagonist III, 4-IPP, 4-Iodo-6-phenylpyrimidine
    参考
    参考 Winner, M., et al. 2008. Cancer Res. 68, 7253.
    产品信息
    CAS号 41270-96-6
    形式 Amber solid
    Hill配方 C₁₀H₇IN₂
    化学配方 C₁₀H₇IN₂
    Molar Mass 282.1
    结构配方图像
    生物信息
    纯度 ≥90% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475846,MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

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