merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

  • merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

    产品名称：Anti-Synaptotagmin I Antibody
    产品型号：MAB5200
    This Anti-Synaptotagmin I Antibody is validated for use in IP, WB, IC for the detection of Synaptotagmin I.

    merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

  • 产品介绍
  • merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Shk, B, Ch, M, R, Rb, FgICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5200
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Synaptotagmin I Antibody
    Alternate Names
    • Syt1
    • p65
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid in PBS with 50% glycerol and 0.09% sodium azide.
    应用
    应用 This Anti-Synaptotagmin I Antibody is validated for use in IP, WB, IC for the detection of Synaptotagmin I.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western blot: 5 μg/mL (colormetric) Immunocytochemistry

    Immunoprecipitation

    Optimal working dilutions and protocols must be determined by the end user.
    生物信息
    免疫原品种 Rat brain synaptotagmin.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Synaptotagmin 1, also known as p65. By Western blot MAB5200 reacts with a single protein with a molecular weight of approximately 65 kDa. MAB5200 has not been epitope mapped.
    同种型 IgG2a
    品种反应性 SharkBovineChickenMouseRatRabbitFrog
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005639.1
    Entrez基因汇总 The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM]
    基因符号
    • Synaptotagmin-1
    • SYT1
    • DKFZp781D2042
    • SVP65
    • SytI
    • SYT
    • p65
    • P65
    UniProt编号
    • P21579
    UniProt汇总 FUNCTION: SwissProt: P21579 # May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
    COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity).
    SIZE: 422 amino acids; 47573 Da
    SUBUNIT: Homotetramer (Probable). Interacts with STN2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity).
    SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note=Synaptic vesicles and chromaffin granules.
    DOMAIN: SwissProt: P21579 The first C2 domain mediates Ca(2+)-dependent phospholipid binding. & The second C2 domain mediates interaction with SV2A and STN2 (By similarity).
    SIMILARITY: Belongs to the synaptotagmin family. & Contains 2 C2 domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots up to 12 months.Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

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