merck millipore,默克密理愽
  • merck millipore,默克密理博,553510,RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

  • merck millipore,默克密理博,553510,RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

    产品名称：RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem
    产品型号：553510
    A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its act More>>

    merck millipore,默克密理博,553510,RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553510,RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₆Br₂N₂O₃S312756-74-4
    描述
    概述 A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.
    产品目录编号 553510
    品牌系列 Calbiochem®
    同义词 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1
    参考
    参考 Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 15848.
    产品信息
    CAS号 312756-74-4
    形式 Light beige solid
    Hill配方 C₂₀H₁₆Br₂N₂O₃S
    化学配方 C₂₀H₁₆Br₂N₂O₃S
    Molar Mass 524.2
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553510,RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

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