merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

  • merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

    产品名称：Anti-Potassium Channel Kir2.1 Antibody
    产品型号：AB5374-200UL
    Anti-Potassium Channel Kir2.1 Antibody detects level of Potassium Channel Kir2.1 & has been published & validated for use in IH & WB.

    merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5374-200UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kir2.1 Antibody
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel Kir2.1 Antibody detects level of Potassium Channel Kir2.1 & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:200 using ECL on rat brain and rat heart membranes.

    Immunohistochemistry on rat heart sections. Note: addition of 0.1% Tween to the standard milk block is recommended for this lot.

    Immunohistochemistry on rat heart sections.

    Dilutions should be made using a carrier protein such as BSA (1-3%).

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified peptide from human Kir2.1 (amino acids 392-410) (Accession P48049).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Kir2.1 protein. The epitope is specific for Kir2.1 and is not present in any other known protein.

    SPECIES REACTIVITIES: The immunogen sequence is identical in rabbit, bovine, porcine and guinea pig. It is highly homologous in rat and mouse (17/19 residues) and chick (15/19 residues). Other species have not been tested.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000891.2
    Entrez基因汇总 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
    基因符号
    • LQT7
    • KCNJ2
    • IRK1
    • HIRK1
    • Kir2.1
    • HHBIRK1
    • SQT3
    • HHIRK1
    • KIR2.1
    UniProt编号
    • P63252
    UniProt汇总 FUNCTION: SwissProt: P63252 # Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
    SIZE: 427 amino acids; 48288 Da
    SUBUNIT: Homomultimeric and heteromultimeric association with Kir2.3, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
    DISEASE: SwissProt: P63252 # Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7) [MIM:170390]; also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. & Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3) [MIM:609622]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.
    SIMILARITY: SwissProt: P63252 ## Belongs to the inward rectifier-type potassium channel family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

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