merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4703,Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18

  • merck millipore,默克密理博,MAB4703,Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18

    产品名称：Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18
    产品型号：MAB4703
    Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18 detects level of Caspase 3 & has been published & validated for use in WB, IH(P).

    merck millipore,默克密理博,MAB4703,Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18

  • 产品介绍
  • merck millipore,默克密理博,MAB4703,Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4703
    Replaces 04-439
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18
    Alternate Names
    • CPP32
    产品信息
    格式 Purified
    控制
    • POSITIVE CONTROL: 293 (human embryonic kidney) cell lysates
    演示 Purified immunoglobulin by protein A. Liquid in PBS, pH 7.6, with 0.1% sodium azide.
    应用
    应用 Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18 detects level of Caspase 3 & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000. The antibody will detect a band at 32 kDa corresponding to the inactive unprocessed form of caspase 3 as well as a 17-22 kDa band corresponding to the large subunit of active caspase 3.

    Immunohistochemistry (frozen and paraffin): 1:500.



    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant full-length human caspase-3 protein
    表位 large subunit & proform
    克隆 4-1-18
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the full length 32 kDa caspase-3 protein. Highly specific to caspase-3 and shows no cross-reaction with other caspase family members. Caspase-3 is ubiquitously expressed and like other caspases is synthesized as an inactive proenzyme. Upon activation, caspase-3 is cleaved generating two smaller subunits of 17 kDa and 12 kDa. Caspase-3 is one of the most extensively studied enzyme in apoptosis. Activation of caspase-3 occurs in response to a variety of apoptotic inducers.
    同种型 IgG2aκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_032991.2
    • NM_004346.3
    Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
    基因符号
    • Caspase-3 subunit p12].
    • CASP3
    • apopain
    • CASP-3
    • procaspase3
    • CPP32B
    • SCA-1
    • CPP-32
    • Apopain
    • CPP32
    • Yama
    • EC 3.4.22.56 [Contains: Caspase-3 subunit p17
    UniProt编号
    • P42574
    UniProt汇总 FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
    SIZE: 277 amino acids; 31608 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
    PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
    SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4703,Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18

上一件merck millipore产品：merck millipore,默克密理博,14-699M,PAK5 Protein, active, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,MAB8258B-5,Anti-Influenza A Antibody, nucleoprotein, clone A3


相关产品

merck millipore,默克密理博,MAB3303,Anti-Collagen Type VI Antibody, clone VI-26 merck millipore,默克密理博,MAB3303,Anti-Collagen Type VI Antibody, clone VI-26

merck millipore,默克密理博,324788,DAPK Inhibitor - CAS 315694-89-4 - Calbiochem merck millipore,默克密理博,324788,DAPK Inhibitor - CAS 315694-89-4 - Calbiochem

merck millipore,默克密理博,12-539,Abltide, biotin conjugate merck millipore,默克密理博,12-539,Abltide, biotin conjugate

merck millipore,默克密理博,AB6048,Anti-Dynactin subunit 1 Antibody merck millipore,默克密理博,AB6048,Anti-Dynactin subunit 1 Antibody

merck millipore,默克密理博,14-699M,PAK5 Protein, active, 250 µg merck millipore,默克密理博,14-699M,PAK5 Protein, active, 250 µg

merck millipore,默克密理博,MAB8258B-5,Anti-Influenza A Antibody, nucleoprotein, clone A3 merck millipore,默克密理博,MAB8258B-5,Anti-Influenza A Antibody, nucleoprotein, clone A3

merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody merck millipore,默克密理博,AB5374-200UL,Anti-Potassium Channel Kir2.1 Antibody

merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody merck millipore,默克密理博,MAB5200,Anti-Synaptotagmin I Antibody

merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

merck millipore,默克密理博,14-439,MAP Kinase 1/Erk1 Protein, active, 10 µg merck millipore,默克密理博,14-439,MAP Kinase 1/Erk1 Protein, active, 10 µg


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部