merck millipore,默克密理愽
  • merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

  • merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

    产品名称：Anti-phospho LSF (Ser291) Antibody
    产品型号：ABE179
    Anti-phospho LSF (Ser291) Antibody is a rabbit polyclonal antibody for detection of phospho LSF (Ser291) also known as Alpha-globin transcription factor CP2, SAA3 enhancer factor, Transcription factor More>>

    merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE179
    描述 Anti-phospho LSF (Ser291) Antibody
    Alternate Names
    • Transcription factor LSF
    • Alpha-globin transcription factor CP2
    • SAA3 enhancer factor
    背景信息 Transcription factor LSF, also known as alpha-globin transcription factor CP2, binds to DNA as a dimer and directly interacts with the alpha-globin promoter to activate transcription. Studies suggest transcription factor LSF regulates erythroid gene expression and plays a key role in the transcriptional switch of globin gene promoters. This protein has also been demonstrated to bind to a number of different cellular and viral promoters such as fibrinogen, alpha-globin, SV40 and HIV-1.
    产品信息
    格式 Affinity Purified
    控制
    • Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho LSF (Ser291) Antibody is a rabbit polyclonal antibody for detection of phospho LSF (Ser291) also known as Alpha-globin transcription factor CP2, SAA3 enhancer factor, Transcription factor LSF & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human LSF phosphorylated at Ser291.
    表位 Phosphorylated Ser291
    宿主 Rabbit
    特异性 This antibody recognizes LSF phosphorylated at Ser291.
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005644
    Entrez基因汇总 This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq].
    基因符号
    • SEF
    • LSF
    • TFCP2
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q12800
    UniProt汇总 FUNCTION: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

    SUBUNIT STRUCTURE: Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.

    SUBCELLULAR LOCATION: Nucleus

    TISSUE SPECIFICTY: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).

    DEVELOPMENTAL STAGE: Expressed in fetal erythroid tissue.

    MISCELLANEOUS: In Ref.2 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding.

    SEQUENCE SIMILARITIES: Belongs to the grh/CP2 family. CP2 subfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates.

    Western Blot Analysis: 1:500 dilution of this antibody detected LSF on 10 µg of Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,ABE179,Anti-phospho LSF (Ser291) Antibody

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