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merck millipore,默克密理博,AB9848,Anti-phospho-Synapsin I (Ser62,Ser67) Antibody
产品名称:Anti-phospho-Synapsin I (Ser62,Ser67) Antibody
产品型号:AB9848
Anti-phospho-Synapsin I Antibody (Ser62, Ser67) detects level of phospho-Synapsin I (Ser62) & has been published & validated for use in WB.
merck millipore,默克密理博,AB9848,Anti-phospho-Synapsin I (Ser62,Ser67) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9848 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-phospho-Synapsin I (Ser62,Ser67) Antibody 产品信息 格式 Affinity Purified 演示 Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol. 应用 应用 Anti-phospho-Synapsin I Antibody (Ser62, Ser67) detects level of phospho-Synapsin I (Ser62) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide of amino acids surrounding the phosphoSerine 62,67 site of rat Synapsin I. 宿主 Rabbit 特异性 Synapsin I, phospho Serine 62,67. The antibody recognizes a protein doublet of ~78 kDa corresponding to Synapsin I, phospho Serine 62,67 in lysates from rat cortex. Immunolableing is blocked by preadsorption with the phospho-peptide used as the immunogen but not by the corresponding dephospho-peptide. 品种反应性 Rat Species Reactivity Note The immunogen has 100% homology with mouse and bovine. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_133499.2
- NM_006950.3
Entrez基因汇总 This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. 基因符号 - SYN1b
- SYN1
- SYN1a
- Synapsin-1
- SYNI
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P17600
UniProt汇总 FUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
SIZE: 705 amino acids; 74111 Da
SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse.
PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. 包装信息 数量 100 µL
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