merck millipore,默克密理博,239835,Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3

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merck millipore,默克密理博,239835,Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem
产品名称：Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem
产品型号：239835
Cyclic oligopeptide with immunosuppressant properties.

merck millipore,默克密理博,239835,Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem

产品介绍

merck millipore,默克密理博,239835,Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem

重要规格表

经验配方	CAS号
C₆₂H₁₁₁N₁₁O₁₂	59865-13-3

描述
概述	Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
产品目录编号	239835
品牌系列	Calbiochem®

参考
参考	Yan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press. Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7. Marumo, T., et al. 1995. Hypertension 25, 764. Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877. Fast, D.J., et al. 1993. J. Interferon Res. 13, 235. Liu, J. 1993. Trends Pharmacol. Sci. 14, 182. Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.

参考

Yan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
Marumo, T., et al. 1995. Hypertension 25, 764.
Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.

产品信息
CAS号	59865-13-3
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₆₂H₁₁₁N₁₁O₁₂
化学配方	C₆₂H₁₁₁N₁₁O₁₂
Molar Mass	1202.6
可逆	N
结构配方图像

生物信息
主靶	NOS induced by interlukin-1-α
纯度	≥97% (dry basis)

理化信息
细胞可渗透	N
溶解度	DMSO, EtOH, or MeOH

GHS安全信息
RTECS	GZ4120000

安全信息
R相	R: 40 Limited evidence of a carcinogenic effect.
S相	S: 22-24/25-36/37 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing and gloves.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.