merck millipore,默克密理愽
  • merck millipore,默克密理博,05-667,Anti-phospho-CREB (Ser133) Antibody, clone 10E9

  • merck millipore,默克密理博,05-667,Anti-phospho-CREB (Ser133) Antibody, clone 10E9

    产品名称：Anti-phospho-CREB (Ser133) Antibody, clone 10E9
    产品型号：05-667
    Anti-phospho-CREB (Ser133) Antibody, clone 10E9 is a Mouse Monoclonal Antibody for detection of phospho-CREB (Ser133) also known as active transcription factor CREB & has been validated in WB, ELISA.

    merck millipore,默克密理博,05-667,Anti-phospho-CREB (Ser133) Antibody, clone 10E9

  • 产品介绍
  • merck millipore,默克密理博,05-667,Anti-phospho-CREB (Ser133) Antibody, clone 10E9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ca, H, M, RELISA, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-667
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-CREB (Ser133) Antibody, clone 10E9
    Alternate Names
    • transactivator protein
    • active transcription factor CREB
    • cAMP responsive element binding protein 1
    • cAMP-response element-binding protein-1
    背景信息 CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.
    产品信息
    格式 Purified
    控制
    • Forskolin-treated PC12 cell lysate
    演示 Purified mouse monoclonal IgG1κ from serum-free cell culture supernatant, lyophilized from 1 mL of PBS, 0.09% sodium azide, PEG, and sucrose. Lyophilized.
    应用
    应用 Anti-phospho-CREB (Ser133) Antibody, clone 10E9 is a Mouse Monoclonal Antibody for detection of phospho-CREB (Ser133) also known as active transcription factor CREB & has been validated in WB, ELISA.
    主要应用
    • ELISA
    • Western Blotting
    应用说明 ELISA: Recommended at 0.05 μg/mL by an independent laboratory.
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide (REILSRRP(pS)YR) corresponding to amino acids 125-135 of human CREB. The immunizing sequence is identical in human and mouse. Clone 10E9.
    克隆 clone 10E9
    宿主 Mouse
    特异性 Recognizes phosphorylated CREB at Mr 46 kDa. May also recognize p30 and p38 proteins, which likely correspond to phosphorylated CREM and ATF-1 respectively, since the two proteins share significant homology with the phosphorylated CREB immunizing peptide
    同种型 IgG1κ
    品种反应性 CanineHumanMouseRat
    Species Reactivity Note Human, rat, canine and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_134442
    Entrez基因汇总 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
    基因符号
    • MGC9284
    • CREB1
    • CREB
    修改
    • Phosphorylation
    纯化方法 Thiophilic adsoption and size exclusion chromatography
    UniProt编号
    • P16220
    UniProt汇总 FUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
    SIZE: 341 amino acids; 36688 Da
    SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.
    产品使用声明
    质量保证 Evaluated by western blot on whole cells lysates from rat PC12 cells treated with forskolin.

    Western Blot Analysis: 0.5-2 μg/mL of this antibody detected phosphorylated CREB in whole cell lysates from HepG2 and PC12 cells treated with forskolin.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Lyophilized: Stable for 1 year at -20ºC from date of receipt.
    Rehydrated: Stable for 3 months at 2-8ºC.
    Aliquot solution to store frozen and avoid repeated freeze thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-667,Anti-phospho-CREB (Ser133) Antibody, clone 10E9

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