- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB4350 描述 Anti-BMP-7 Antibody, clone 2A10 背景信息 Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4),
150 mM NaCl, and 0.05% sodium azide.应用 应用 This Anti-BMP-7 Antibody, clone 2A10 is validated for use in WB, IH for the detection of BMP-7. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry: Recommended working dilution is 1:50.
Western Blotting: Recommended working concentration is 1 – 2 µg/mL.生物信息 免疫原品种 Recombinant full-length BMP-7 protein. 克隆 2A10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This monoclonal antibody recognizes BMP-7. 同种型 IgG1κ 品种反应性 MouseHuman Species Reactivity Note Reacts with human and mouse. Reactivity with other species has not been tested. 抗体类型 Monoclonal Antibody 纯化方法 Protein G purfied UniProt编号 - P18075
UniProt汇总 Function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.
Subcellular location Secreted.
Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.
Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).
Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
Sequence similarities Belongs to the TGF-beta family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,219511,Cdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,06-920,Anti-Smad3 Antibody
相关产品
merck millipore,默克密理博,CA1023,Anti-Hsp90α Mouse mAb (EMD-17D7)
merck millipore,默克密理博,71558,pTriEx™-5 DNA - Novagen
merck millipore,默克密理博,AB5352,Anti-Amyloid Precursor Protein Antibody, CT
merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem
merck millipore,默克密理博,219511,Cdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem
merck millipore,默克密理博,06-920,Anti-Smad3 Antibody
merck millipore,默克密理博,05-681,Anti-Smac/DIABLO Antibody, clone 78-1-118
merck millipore,默克密理博,12-552,TK Substrate 1
merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody
merck millipore,默克密理博,SF-437,miR-183-5p; Human, Cyanine 5, RNA Detection Probe,SmartFlare