merck millipore,默克密理愽
  • merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

  • merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

    产品名称：Anti-Nicotinic Acetylcholine Receptor α7 Antibody
    产品型号：AB15332
    This Anti-Nicotinic Acetylcholine Receptor α7 Antibody is validated for use in WB for the detection of Nicotinic Acetylcholine Receptor α7.

    merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15332
    Replaces AB5637
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nicotinic Acetylcholine Receptor α7 Antibody
    产品信息
    格式 Affinity Purified
    演示 Liquid in PBS containing 0.1% sodium azide.
    应用
    应用 This Anti-Nicotinic Acetylcholine Receptor α7 Antibody is validated for use in WB for the detection of Nicotinic Acetylcholine Receptor α7.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Nictotinic Receptor alpha 7. By Western blot the antibody recognizes a band at ~56 kDa in mouse brain lysate.
    品种反应性 Mouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000746.3
    Entrez基因汇总 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.
    基因符号
    • NACHRA7
    • CHRNA7
    UniProt编号
    • P36544
    UniProt汇总 FUNCTION: SwissProt: P36544 # After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
    SIZE: 502 amino acids; 56449 Da
    SUBUNIT: Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.
    SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
    SIMILARITY: SwissProt: P36544 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

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