merck millipore,默克密理愽
  • merck millipore,默克密理博,06-920,Anti-Smad3 Antibody

  • merck millipore,默克密理博,06-920,Anti-Smad3 Antibody

    产品名称：Anti-Smad3 Antibody
    产品型号：06-920
    Detect Smad3 with Anti-Smad3 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.

    merck millipore,默克密理博,06-920,Anti-Smad3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-920,Anti-Smad3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-920
    Replaces 04-1035
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Smad3 Antibody
    背景信息 Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5 and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression.
    产品信息
    格式 Purified
    控制
    • HepG2 cell lysate
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect Smad3 with Anti-Smad3 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide [C-NLSPNPMSPAHNNLD-amide] corresponding to amino acids 206-220 of human Smad3
    宿主 Rabbit
    特异性 Smad3
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_022739
    基因符号
    • DKFZP586N0721
    • SMAD3
    • MADH3
    • JV15-2
    • DKFZp686J10186
    • hSMAD3
    • hMAD-3
    • HSPC193
    • MGC60396
    • HsT17436
    • Mad3
    纯化方法 Protein A chromatography
    UniProt编号
    • P84022
    UniProt汇总 FUNCTION: SwissProt: P84022 # Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).
    SIZE: 425 amino acids; 48081 Da
    SUBUNIT: Interacts with HGS. Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co- SMAD SMAD4. Interacts with JUN/FOS, vitamin D receptor, homeobox protein TGIF and TGIF2, PEBP2-alpha C subunit, CREB-binding protein (CBP), p300, SKI, SNON, ATF2, SMURF2, AIP1, DACH1 and TGFB1I1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Found in a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Interacts with SMAD2 and TRIM33. Found in a complex with SMAD3, Ran and XPO4. Interacts with XPO4.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
    DOMAIN: SwissProt: P84022 The MH2 domain is sufficient to carry protein nuclear export.
    PTM: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.DISEASE:SwissProt: P84022 # Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500].
    SIMILARITY: Belongs to the dwarfin/SMAD family. & Contains 1 MH1 (MAD homology 1) domain. & Contains 1 MH2 (MAD homology 2) domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from HepG2 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 400 µg

    merck millipore,默克密理博,06-920,Anti-Smad3 Antibody

上一件merck millipore产品：merck millipore,默克密理博,MAB4350,Anti-BMP-7 Antibody, clone 2A10
下一件merck millipore产品：merck millipore,默克密理博,05-681,Anti-Smac/DIABLO Antibody, clone 78-1-118


相关产品

merck millipore,默克密理博,71558,pTriEx™-5 DNA - Novagen merck millipore,默克密理博,71558,pTriEx™-5 DNA - Novagen

merck millipore,默克密理博,AB5352,Anti-Amyloid Precursor Protein Antibody, CT merck millipore,默克密理博,AB5352,Anti-Amyloid Precursor Protein Antibody, CT

merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

merck millipore,默克密理博,219511,Cdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem merck millipore,默克密理博,219511,Cdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem

merck millipore,默克密理博,MAB4350,Anti-BMP-7 Antibody, clone 2A10 merck millipore,默克密理博,MAB4350,Anti-BMP-7 Antibody, clone 2A10

merck millipore,默克密理博,05-681,Anti-Smac/DIABLO Antibody, clone 78-1-118 merck millipore,默克密理博,05-681,Anti-Smac/DIABLO Antibody, clone 78-1-118

merck millipore,默克密理博,12-552,TK Substrate 1 merck millipore,默克密理博,12-552,TK Substrate 1

merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody merck millipore,默克密理博,AB15332,Anti-Nicotinic Acetylcholine Receptor α7 Antibody

merck millipore,默克密理博,SF-437,miR-183-5p; Human, Cyanine 5, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-437,miR-183-5p; Human, Cyanine 5, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,SCGVU05RE,Stericup-GV，0.22 µm，PVDF，500 mL，射线灭菌 merck millipore,默克密理博,SCGVU05RE,Stericup-GV，0.22 µm，PVDF，500 mL，射线灭菌


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部