merck millipore,默克密理愽
  • merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

  • merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

    产品名称：Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem
    产品型号：528284
    The Polo-like Kinase Inhibitor III, also referenced under CAS 660868-91-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & D More>>

    merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₈F₃N₃O₄S660868-91-7
    描述
    概述 A cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases (K i against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 µM) over normal human diploid fibroblasts (IC50 = 6.14 µM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
    产品目录编号 528284
    品牌系列 Calbiochem®
    同义词 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)-benzyl)oxy)thiophene-2-carboxamide, Plk Inhibitor III
    参考
    参考 Johnson, E.F., et al. 2007. Biochemistry 46, 9551.
    Lansing, T.J., et al. 2007. Mol. Cancer Ther. 6, 450.
    产品信息
    CAS号 660868-91-7
    形式 Off-white solid
    Hill配方 C₂₂H₁₈F₃N₃O₄S
    化学配方 C₂₂H₁₈F₃N₃O₄S
    Molar Mass 477.5
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36/37-45

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing and gloves.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528284,Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,219511,Cdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem


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