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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-681 Replaces 04-578 品牌系列 Upstate
商名 - Upstate
描述 Anti-Smac/DIABLO Antibody, clone 78-1-118 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Smac/DIABLO using this Anti-Smac/DIABLO Antibody, clone 78-1-118 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 His6 fusion protein corresponding to residues 56-239 of human Smac/DIABLO 克隆 78-1-118 宿主 Mouse 特异性 Smac/DIABLO 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_138929
Entrez基因汇总 This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. 基因符号 - SMAC3
- DIABLO
- SMAC
- DIABLO-S
- FLJ25049
- 0610041G12Rik
- diablo
- FLJ10537
纯化方法 Protein G chromatography UniProt编号 - Q9NR28
UniProt汇总 FUNCTION: SwissProt: Q9NR28 # Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
SIZE: 239 amino acids; 27131 Da
SUBUNIT: Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, BIRC4/XIAP and BIRC7.
SUBCELLULAR LOCATION: Mitochondrion. Note=But released into the cytosol when cells undergo apoptosis.
TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
DOMAIN:SwissProt: Q9NR28 The mature N-terminus mediates interaction with BIRC4/XIAP.
SIMILARITY:产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from HEK 293 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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