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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, ELISA, WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB4311 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Nucleostemin Antibody 背景信息 Nucleostemin has been identified as a nucleolar protein that plays a role in the self-renewal mechanism of a variety of stem cells. Analysis of gene expression showed that both undifferentiated ES cells, Neural & Hematopoietic stem cells and a number of cancer cells express Nucleostemin. Expression was not detected following stem cell differentiation into mature cell types. The identification of factors that influence self renewal are important for the development of therapeutic applications of stem cells and also for the development of cancer treatments. Monoclonal antibodies to Human nucleostemin will facilitate the analysis of self-renewal in both stem cells and cancer cells. 产品信息 格式 Culture Supernatant 演示 Static cell culture supernatant fluid 应用 应用 Detect Nucleostemin using this Anti-Nucleostemin Antibody validated for use in ELISA, WB & IC. 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
生物信息 免疫原品种 Recombinant GST-Human fusion protein 克隆 9D5.3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_206826.1
- NM_014366.4
- NM_206825.1
基因符号 - nucleostemin
- GNL3
- C77032
- Nucleostemin
- NS
- MGC800
- NNP47
- E2IG3
UniProt编号 - Q9BVP2
UniProt汇总 FUNCTION: SwissProt: Q9BVP2 # May be required to maintain the proliferative capacity of stem cells.
SIZE: 549 amino acids; 61997 Da
SUBUNIT: May interact with p53/TP53 via its basic domain (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Shuttles between the nucleus and nucleolus (By similarity).
DOMAIN: SwissProt: Q9BVP2 The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µL
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