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merck millipore,默克密理博,574662,Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem
产品名称：Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem
产品型号：574662
The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.
merck millipore,默克密理博,574662,Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₉BrN₄O₃ 781661-94-7 描述 概述 A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively. 产品目录编号 574662 品牌系列 Calbiochem®
同义词 Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor 参考 参考 Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
Nakahara, T., et al. 2007, Cancer Res. 67, 8014.产品信息 CAS号 781661-94-7 形式 Yellow solid Hill配方 C₂₀H₁₉BrN₄O₃ Molar Mass 443.3 可逆 Y 结构配方图像 生物信息 主靶 Interleukin enhancer-binding factor 3 (ILF3/NF110) 主靶IC50 540nM 副靶 Unknown 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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