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经验配方 C₂₄H₂₉FN₂O₄S 描述 概述 A cell-permeable anthranilic acid sulfonamide compound that acts as a potent and reversible inhibitor of methionine aminopetidase-2 (MetAP2, IC50 = 11 nM). Acts by directly targeting the active site of MetAP2 without any significant binding to human serum albumin. Also shown to inhibit cellular MetAP2 activity (EC50 = 5.3 nM) and block the proliferation of HT1080 fibrosarcoma cells (EC50 = 6 nM). 产品目录编号 654271 品牌系列 Calbiochem®
同义词 Methionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor 参考 参考 Sheppard, G. S., et al. 2006. J Med Chem. 49, 3832 产品信息 形式 Light beige solid Hill配方 C₂₄H₂₉FN₂O₄S Molar Mass 460.56 可逆 Y 结构配方图像 生物信息 主靶 MetAP2 主靶IC50 11 nM 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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