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品种反应性 主要应用 宿主 格式 抗体类型 Po, H, Ht IHC, ELISA, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB325 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Syntaxin Antibody, clone SP7 Alternate Names - STX1A
- Syntaxin 1A
- Neuron-specific Antigen HPC-1
产品信息 格式 Ascites 演示 Liquid 应用 应用 Anti-Syntaxin Antibody, clone SP7 is an antibody against Syntaxin for use in ELISA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
应用说明 Immunohistochemistry:1:10
Formalin fixed (fixed <4 weeks)
Immunoblotting: 1:10
ELISA: 1:10
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Crude synaptic immunoprecipitate (human). 克隆 SP7 宿主 Mouse 特异性 Syntaxin (34-36 kDa). Reacts with syntaxin expressed in bacterial systems. Useful to investigators who transplant human neurons or human neural derived cell lines into rodents since the antibody reacts with human but poorly with rat syntaxin. Also useful in double labeling studies due to the fact it is an IgG2a subclass monoclonal. 同种型 IgG2a 品种反应性 PigHumanHamster 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004603.2
Entrez基因汇总 Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM] 基因符号 - p35-1
- STX1A
- HPC-1
- STX1
- Syntaxin-1A
UniProt编号 - Q16623
UniProt汇总 FUNCTION: SwissProt: Q16623 # Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.
SIZE: 288 amino acids; 33023 Da
SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25 (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein. & Isoform 2: Secreted (Probable).
TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
DISEASE: SwissProt: Q16623 # Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
SIMILARITY: SwissProt: Q16623 ## Belongs to the syntaxin family. & Contains 1 t-SNARE coiled-coil homology domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µL
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