merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3612,Anti-Caspase 12 Antibody, prodomain, aa 100-116

  • merck millipore,默克密理博,AB3612,Anti-Caspase 12 Antibody, prodomain, aa 100-116

    产品名称：Anti-Caspase 12 Antibody, prodomain, aa 100-116
    产品型号：AB3612
    Detect Caspase 12 using this Anti-Caspase 12 Antibody, prodomain, aa 100-116 validated for use in WB, IH.

    merck millipore,默克密理博,AB3612,Anti-Caspase 12 Antibody, prodomain, aa 100-116

  • 产品介绍
  • merck millipore,默克密理博,AB3612,Anti-Caspase 12 Antibody, prodomain, aa 100-116

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3612
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caspase 12 Antibody, prodomain, aa 100-116
    背景信息 Three distinct signaling pathways lead to apoptosis. The death receptor and mitochondrion are the two main pathways which involve caspase-8 and caspase-9, respectively. The endoplasmic reticulum stress is the third apoptotic pathway and involves caspase-12. Localized to the ER but not to cytoplasm or mitochondria, caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including γ-secretase presenilin and ß-amyloid precursor protein (APP). Caspase-12 mediates ER stress-induced apoptosis as well as cytotoxicity induced by amyloid-ß. Caspase-12 is ubiquitously expressed in mouse tissues.
    产品信息
    格式 Affinity Purified
    控制
    • Positive: mouse brain tissue lysate
    演示 Immunoaffinity chromatography purified antibody supplied in PBS containing 0.02% sodium azide.
    应用
    应用 Detect Caspase 12 using this Anti-Caspase 12 Antibody, prodomain, aa 100-116 validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western blot: 0.5 μg - 1 μg. Detects a band at ~49-53 kDa. in normal tissue extracts. Caspase-12 is a stress induced caspase localized to the ER and activated upon ER stress. Active process forms are difficult to detect in most non-transfected systems. Not all cells produce caspase-12; mouse L929 fibrosacrcoma cells are an excellent positive control line.

    Immunohistochemistry: 2 μg /mL in mouse liver tissue

    Mouse brain tissue lysate can be used as a positive control. Caspase 12 is associated with ER membranes and not in cytoplasm or mitochondria. Caspase 12 mediates cytotoxixity induced by amyloid beta.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 100-116 of murine caspase-12.
    表位 prodomain, aa 100-116
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Antibody recognizes caspase-12 pro-protein in mouse extracts of normal and apoptotic cells. Caspase-12 is predicted to have a large, >120 aa, long prodomain region. Thus this antibody recognizes only the proforms of the enzyme and not the active subunits. Uncleaved (proform) caspase-12 is prominently detected in many tissues. Active forms are difficult to detect expect in transfect cell systems. {Kalai, M et al (2003) 162:457-467}.
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因汇总 Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis.
    基因符号
    • CASP12P1
    • CASP12
    • Caspase-12.
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q6UXS9
    UniProt汇总 SIZE: 341 amino acids; 38907 Da
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2°-8°C for up to one year from date of receipt
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB3612,Anti-Caspase 12 Antibody, prodomain, aa 100-116

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