merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3324,Anti-Cathepsin K Antibody, clone 182-12G5

  • merck millipore,默克密理博,MAB3324,Anti-Cathepsin K Antibody, clone 182-12G5

    产品名称：Anti-Cathepsin K Antibody, clone 182-12G5
    产品型号：MAB3324
    Anti-Cathepsin K Antibody, clone 182-12G5 detects level of Cathepsin K & has been published & validated for use in WB.

    merck millipore,默克密理博,MAB3324,Anti-Cathepsin K Antibody, clone 182-12G5

  • 产品介绍
  • merck millipore,默克密理博,MAB3324,Anti-Cathepsin K Antibody, clone 182-12G5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3324
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cathepsin K Antibody, clone 182-12G5
    产品信息
    格式 Purified
    演示 Liquid in 0.1 M Sodium-Phosphate buffer, pH 7.0 containing 2% protease-free bovine serum albumin. No preservatives.
    应用
    应用 Anti-Cathepsin K Antibody, clone 182-12G5 detects level of Cathepsin K & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Immunoblotting. When used at a 2-5 μg/mL concentration to detect purified human cathepsin K from giant cell tumor at 0.7 μg/lane, this antibody detects a band at approximately 28 kDa.

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 182-12G5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Antibody MAB3324 is directed against a synthetic peptide corresponding to amino acids 182-195 of cathepsin K from human osteoarthritic hip bone. Specifically reacts with the human cathepsin K.
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000396.2
    Entrez基因汇总 The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
    基因符号
    • EC 3.4.22.38
    • CTSK
    • CTSO2
    • CTSO
    • CTSO1
    • PKND
    • CTS02
    • PYCD
    • MGC23107
    UniProt编号
    • P43235
    UniProt汇总 FUNCTION: SwissProt: P43235 # Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
    SIZE: 329 amino acids; 36966 Da
    SUBCELLULAR LOCATION: Lysosome.
    TISSUE SPECIFICITY: Predominantly expressed in osteclasts (bones).
    DISEASE:SwissProt: P43235 # Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
    SIMILARITY: SwissProt: P43235 ## Belongs to the peptidase C1 family.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3324,Anti-Cathepsin K Antibody, clone 182-12G5

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