merck millipore,默克密理博,ABS590,Anti-PYCR2 Antibody

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merck millipore,默克密理博,ABS590,Anti-PYCR2 Antibody
产品名称：Anti-PYCR2 Antibody
产品型号：ABS590
Anti-PYCR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Pyrroline-5-carboxylate reductase 2 & has been tested in western blotting, IHC & Immunofluorescence.

merck millipore,默克密理博,ABS590,Anti-PYCR2 Antibody

产品介绍

merck millipore,默克密理博,ABS590,Anti-PYCR2 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABS590
描述	Anti-PYCR2 Antibody
Alternate Names	PYCR2 Pyrroline-5-carboxylate reductase 2 P5C reductase 2 P5CR 2
背景信息	The enzyme named Pyrroline-5-carboxylate reductase 2 (P5C reductase 2, P5CR2), and encoded by the human gene named PYCR2 is a mitochondrial protein enzyme that catalyzes the last step in proline biosynthesis. PYCR2 is also a critical provider of NADP for energy metabolism in certain cells types such as red blood cells. Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In cancer, tumor cells tend to rely on proline biosynthesis rather than salvage for protein production. Proline is synthesized from either glutamate or ornithine, and both are converted to pyrroline-5-carboxylate (P5C), and then to proline via PYCR2 or PYCR1 reductases. As such, PYCR2 may be a potential target for anti-cancer therapy. Additionally, the expression of PYCR2 is thought to be influenced by a miRNA control mechanism specifically that of miR-143. Therefore, miR143 is also a target of active research in cancer and apoptosis.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Anti-PYCR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Pyrroline-5-carboxylate reductase 2 & has been tested in western blotting, IHC & Immunofluorescence.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PYCR2 in human ovary tissue. Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected PYCR2 in HeLa cells.

生物信息
免疫原品种	GST-tagged fusion protein corresponding to human PYCR2.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	PYCR2
纯化方法	Antigen Affinity purified
UniProt编号	Q96C36

产品使用声明
质量保证	Evaluated by Western Blotting in Jurkat cell lysate. Western Blotting Analysis: A 1:800 dilution of this antibody detected PYCR2 in Jurkat cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.