merck millipore,默克密理愽
  • merck millipore,默克密理博,AB4087,Anti-Protein Phosphatase 2 A/B δ Antibody

  • merck millipore,默克密理博,AB4087,Anti-Protein Phosphatase 2 A/B δ Antibody

    产品名称：Anti-Protein Phosphatase 2 A/B δ Antibody
    产品型号：AB4087
    Detect Protein Phosphatase 2 A/B δ using this Anti-Protein Phosphatase 2 A/B δ Antibody validated for use in IF & WB.

    merck millipore,默克密理博,AB4087,Anti-Protein Phosphatase 2 A/B δ Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB4087,Anti-Protein Phosphatase 2 A/B δ Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, B, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB4087
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Protein Phosphatase 2 A/B δ Antibody
    背景信息 PP2A is a heterotrimeric phosphatase, composed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma. The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. Bdelta is a novel isoform of the B class of PP2A regulatory subunits. It is widely expressed in rat tissues and appears to be involved in targeting PP2A to the cytosolic compartment.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Provided as 0.2μm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.
    应用
    应用 Detect Protein Phosphatase 2 A/B δ using this Anti-Protein Phosphatase 2 A/B δ Antibody validated for use in IF & WB.
    主要应用
    • Western Blotting
    应用说明 Western blot

    Immunofluorescence

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide conjugated to KLH derived from the N-terminus of PP2A/B delta.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes the Bdelta regulatory subunit isotype of protein phosphatase 2A (PP2A).
    同种型 IgG
    品种反应性 RatBovineHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_180977.1
    • NM_006245.2
    • NM_180976.1
    Entrez基因汇总 The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
    基因符号
    • B56D
    • PPP2R5D
    • MGC8949
    • MGC2134
    • OTTHUMP00000039821
    UniProt编号
    • Q14738
    UniProt汇总 FUNCTION: SwissProt: Q14738 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
    SIZE: 602 amino acids; 69992 Da
    SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
    TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: Q14738 ## Belongs to the phosphatase 2A regulatory subunit B56 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB4087,Anti-Protein Phosphatase 2 A/B δ Antibody

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