merck millipore,默克密理愽
  • merck millipore,默克密理博,06-646,Anti-Flt-3 Antibody, extracellular region

  • merck millipore,默克密理博,06-646,Anti-Flt-3 Antibody, extracellular region

    产品名称：Anti-Flt-3 Antibody, extracellular region
    产品型号：06-646
    This Anti-Flt-3 Antibody, extracellular region is validated for use in FC, IP, WB, IC for the detection of Flt-3.

    merck millipore,默克密理博,06-646,Anti-Flt-3 Antibody, extracellular region

  • 产品介绍
  • merck millipore,默克密理博,06-646,Anti-Flt-3 Antibody, extracellular region

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, FC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-646
    Replaces CBL1364
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Flt-3 Antibody, extracellular region
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide
    应用
    应用 This Anti-Flt-3 Antibody, extracellular region is validated for use in FC, IP, WB, IC for the detection of Flt-3.
    主要应用
    • Immunocytochemistry
    • Flow Cytometry
    • Western Blotting
    生物信息
    免疫原品种 Bafl-3 cells, a murine pro-B cell line expressing the Flt3 receptor, injected into rabbits
    宿主 Rabbit
    特异性 mature form of Flt3
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004119
    Entrez基因汇总 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
    基因符号
    • STK1
    • FLT3
    • STK-1
    • CD135
    • FLK2
    • OTTHUMP00000042340
    纯化方法 Protein A chromatography
    UniProt编号
    • P36888
    UniProt汇总 FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
    SIZE: 993 amino acids; 112903 Da
    SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Bone marrow cells.
    SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from mouse Bafl-3 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-646,Anti-Flt-3 Antibody, extracellular region

上一件merck millipore产品：merck millipore,默克密理博,324483,Ebselen - CAS 60940-34-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MAB1164,Anti-c-Kit Antibody, clone 1DC3


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