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merck millipore,默克密理博,MAB2021Z,Anti-Integrin αV Antibody, extracellular, clone AV1, azide free
产品名称：Anti-Integrin αV Antibody, extracellular, clone AV1, azide free
产品型号：MAB2021Z
Anti-Integrin αV Antibody, extracellular, clone AV1, azide free detects level of Integrin αV & has been published & validated for use in FC & WB.
merck millipore,默克密理博,MAB2021Z,Anti-Integrin αV Antibody, extracellular, clone AV1, azide free
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, FC M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB2021Z 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin αV Antibody, extracellular, clone AV1, azide free Alternate Names - MAB2021
- VitronectinReceptor
- CD51
产品信息 格式 Culture Supernatant 演示 Unpurified tissue culture supernatant from a perfusion system, filtered through a 0.2μ micron membrane prior to vialing. Product contains 20%FBS and Ciprofloxacin at final concentration of 10μg/mL. 应用 应用 Anti-Integrin αV Antibody, extracellular, clone AV1, azide free detects level of Integrin αV & has been published & validated for use in FC & WB. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Flow cytometry: 1:5-1:50
Western Blot. Under non-reducing conditions recognizes a band at approximately 165 kDa corresponding to integrin alphaV. Does not recognize the reduced protein.
Function-blocking of integrin alphaV-mediated adhesion to ECM proteins. (1:5-1:20, in HEPES buffer pH 7.4 containing 1mM Mn++ and 1mM Mg++).
Optimal working dilutions and protocols must be determined by end user.生物信息 免疫原品种 Human integrin alphaVbeta3 heterodimer isolated from placenta. 表位 extracellular, azide free 克隆 AV1 宿主 Mouse 特异性 Specific for human integrin alphaV (other species not tested). 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002210.2
Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. 基因符号 - VNRA
- ITGAV
- DKFZp686A08142
- MSK8
- CD51
UniProt编号 - P06756
UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months.
During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.包装信息 数量 500 µL
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