merck millipore,默克密理愽
  • merck millipore,默克密理博,07-224,Anti-phospho-STAT2 (Tyr689) Antibody

  • merck millipore,默克密理博,07-224,Anti-phospho-STAT2 (Tyr689) Antibody

    产品名称：Anti-phospho-STAT2 (Tyr689) Antibody
    产品型号：07-224
    Detect phospho-STAT2 (Tyr689) also known as signal transducer & activator of transcription 2 with Anti-phospho-STAT2 (Tyr689) Antibody (rabbit polyclonal antibody), that has been demonstrated to work  More>>

    merck millipore,默克密理博,07-224,Anti-phospho-STAT2 (Tyr689) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-224,Anti-phospho-STAT2 (Tyr689) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-224
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-STAT2 (Tyr689) Antibody
    背景信息 The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia. STAT2 (113 kDa), originally purified from the nuclei of a-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of STAT2 exhibit greater susceptibility to viral infection and altered responses to Type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via assocations with receptor-bound Jak kinases.
    产品信息
    格式 Affinity Purified
    控制
    • IFN-gamma then IFN-alpha treated HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect phospho-STAT2 (Tyr689) also known as signal transducer & activator of transcription 2 with Anti-phospho-STAT2 (Tyr689) Antibody (rabbit polyclonal antibody), that has been demonstrated to work in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blotting Analysis:
    A a representative lot of this antibody detected phospho-STAT2 (Tyr689) in 10 µg of IFN alpha/gamma treated HeLa cell lysate.

    Immunoprecipitation Analysis: A representative lot of this antibody immunoprecipitated phospho-STAT2 (Tyr689) from IFN alpha treated HeLa cell lysate.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to mouse STAT2 phosphorylated at Tyr689.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes STAT2 phosphorylated at tyrosine 689.
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005419
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
    基因符号
    • P113
    • STAT2
    • MGC59816
    • p113
    • ISGF-3
    • STAT113
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P52630
    UniProt汇总 FUNCTION: SwissProt: P52630 # Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
    SIZE: 851 amino acids; 97916 Da
    SUBUNIT: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
    PTM: Tyrosine phosphorylated in response to IFN-alpha.
    SIMILARITY: SwissProt: P52630 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    产品使用声明
    质量保证 Evaluated by Western Blotting in HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-224,Anti-phospho-STAT2 (Tyr689) Antibody

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