• merck millipore,默克密理博,444158,MDMX Inhibitor, NSC207895 - Calbiochem
  • merck millipore,默克密理博,444158,MDMX Inhibitor, NSC207895 - Calbiochem

    产品名称:MDMX Inhibitor, NSC207895 - Calbiochem
    产品型号:444158
    The MDMX Inhibitor, NSC207895 controls the biological activity of MDMX. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,444158,MDMX Inhibitor, NSC207895 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444158,MDMX Inhibitor, NSC207895 - Calbiochem

    重要规格表

    经验配方
    C₁₁H₁₃N₅O₄
    描述
    概述 A cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. A great complement to MDM2 antagonist Nutlin-3 (Cat. Nos. 444143 & 444151) in growth inhibition and apoptosis induction of cancer cells that are more sensitive to MDMX than MDM2 inhibition.
    产品目录编号 444158
    品牌系列 Calbiochem®
    同义词 7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole-1-oxide, 7-(4-Methylpiperazin-1-yl)-4-nitro-1-oxido-2,1,3-benzoxadiazol-1-ium, XI-006
    参考
    参考 Wang, H., et al. 2011. Mol. Cancer Ther. 7, 611.
    Berkson, R.G., et al. 2005. Int. J. Cancer 115, 701.
    产品信息
    形式 Dark red solid
    Hill配方 C₁₁H₁₃N₅O₄
    化学配方 C₁₁H₁₃N₅O₄
    Molar Mass 279.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444158,MDMX Inhibitor, NSC207895 - Calbiochem

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