merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1098,Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

  • merck millipore,默克密理博,05-1098,Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

    产品名称：Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2
    产品型号：05-1098
    Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2 detects level of acetyl CoA Carboxylase & has been published & validated for use in WB.

    merck millipore,默克密理博,05-1098,Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

  • 产品介绍
  • merck millipore,默克密理博,05-1098,Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1098
    Replaces 04-322
    描述 Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2
    Alternate Names
    • acetyl-Coenzyme A carboxylase alpha
    • acetyl-CoA carboxylase 1
    • acetyl-CoA carboxylase-alpha
    背景信息 Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes, whereas it is a large, multi-domain enzyme in most eukaryotes. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs - ACACA and ACACB. The activity of the enzyme is controlled by reversible phosphorylation. The activity of the enzyme is inhibited if phosphorylated; the phosphorylation takes place when the hormone glucagon or epinephrine binds to the receptors or the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase. The presence of fatty acid inhibits the activities of the enzyme. When insulin binds to its receptors, it activates a phosphatase to dephosphorylate the enzyme; the activities of the acetyl-CoA carboxylase is thus enhanced. Acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity and antibiotic drugs.
    产品信息
    格式 Purified
    控制
    • Human heart lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2 detects level of acetyl CoA Carboxylase & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: 1 µg/mL from a previous lot detected acetyl CoA Carboxylase on 10 µg of rat heart lysate.

    Western Blot (SNAP ID) Analysis: 1 µg/mL from a previous lot detected acetyl CoA Carboxylase on 10 µg of human heart lysate.
    生物信息
    免疫原品种 Histidine-tagged recombinant protein corresponding to human acetyl CoA Carboxylase.
    克隆 7D2.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 RatHuman
    Species Reactivity Note Demonstrated to react with human and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_942131
    Entrez基因汇总 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriche in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
    基因符号
    • ACCA
    • ACAC
    • ACC
    • ACC-alpha
    • ACC1
    纯化方法 Protein G
    UniProt编号
    • Q13085
    UniProt汇总 FUNCTION: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

    CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

    ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.

    COFACTOR: Biotin.

    Binds 2 manganese ions per subunit.

    ENZYME REGULATION: By phosphorylation (By similarity).

    PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

    SUBUNIT STRUCTURE: Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.

    SUBCELLULAR LOCATION: Cytoplasm.

    TISSUE SPECIFICITY: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

    PTM: Phosphorylation on Ser-1263 is required for interaction with BRCA1.

    INVOLVEMENT IN DISEASE: Defects in ACACA are a cause of ACACA deficiency [MIM:200350]; also called ACAC or ACC deficiency. ACACA deficiency is an inborn error of de novo fatty acid synthesis. The disorder is associated with severe brain damage, persistent myopathy and poor growth.

    SEQUENCE SIMILARITIES: Contains 1 ATP-grasp domain.

    Contains 1 biotin carboxylation domain.

    Contains 1 biotinyl-binding domain.

    Contains 1 carboxyltransferase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in human heart lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected acetyl CoA Carboxylase on 10 µg of human heart lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1098,Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

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