merck millipore,默克密理愽
  • merck millipore,默克密理博,506149,p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

  • merck millipore,默克密理博,506149,p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

    产品名称：p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem
    产品型号：506149
    The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,506149,p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506149,p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₂O₃S₂213261-59-7
    描述
    概述 A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
    产品目录编号 506149
    品牌系列 Calbiochem®
    同义词 NSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
    参考
    参考 Grinkevich, V., et al. 2005. Nat. Med. 11, 1136.
    Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
    Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
    Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
    Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.
    产品信息
    CAS号 213261-59-7
    具有ATP竞争性 N
    形式 Crystalline solid
    Hill配方 C₁₄H₁₂O₃S₂
    化学配方 C₁₄H₁₂O₃S₂
    Molar Mass 292.4
    可逆 N
    结构配方图像
    生物信息
    主靶 p53
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,506149,p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

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