merck millipore,默克密理愽
  • merck millipore,默克密理博,112252,Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

  • merck millipore,默克密理博,112252,Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

    产品名称：Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem
    产品型号：112252
    The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.

    merck millipore,默克密理博,112252,Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,112252,Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

    重要规格表

    经验配方
    C₁₆H₁₈N₈O₄
    描述
    概述 A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50 = 0.92 µM and Ki = 0.42 µM for hAMCase, and IC50= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.
    产品目录编号 112252
    品牌系列 Calbiochem®
    同义词 AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione
    参考
    参考 Sutherland, T.E., et al. 2011. Chem. Biol. 18, 569.
    产品信息
    形式 Off-white powder
    Hill配方 C₁₆H₁₈N₈O₄
    化学配方 C₁₆H₁₈N₈O₄
    Molar Mass 386.37
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,112252,Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

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