merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5848,Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat

  • merck millipore,默克密理博,AB5848,Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat

    产品名称：Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat
    产品型号：AB5848
    This Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat is validated for use in WB for the detection of GABA B Receptor R2.

    merck millipore,默克密理博,AB5848,Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat

  • 产品介绍
  • merck millipore,默克密理博,AB5848,Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5848
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat
    背景信息 The inhibitory neurotransmitter, GABA, acts through two ligand-gated channels, GABA(A) and GABA© receptors and GABA(B), the latter of which acts through a G protein mechanism. GABA(B)R2 is one of the two G-protein coupled receptors for GABA(B) that acts as a heteromeric assembly with GABA(B)R1.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.
    应用
    应用 This Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat is validated for use in WB for the detection of GABA B Receptor R2.
    主要应用
    • Western Blotting
    应用说明 Immunoblotting: 1:500-1:1,000. Membrane preparations with proteinase inhibitors are recommended. Whole rat brain membrane preparations. The antibody detects a ~105kDa band under standard western conditions. The immunogen used is 100% conserved in human by sequence analysis; other species have not been examined for reactivity or homology.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 peptide residues 42-54 of the rat 105 kDa GABA(b)R2 protein
    表位 a.a. 42-54 rat
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 GABAB Receptor R2 subunit, N-terminus. No reactivity with GABABR1 has been detected.
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005458.5
    Entrez基因汇总 B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]
    基因符号
    • GABABR2
    • GABBR2
    • HRIHFB2099
    • OTTHUMP00000063797
    • GPRC3B
    • GPR51
    • HG20
    • Gb2
    • FLJ36928
    • GABA-B-R2
    UniProt编号
    • O75899
    UniProt汇总 FUNCTION: SwissProt: O75899 # Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
    SIZE: 941 amino acids; 105821 Da
    SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
    TISSUE SPECIFICITY: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
    DOMAIN: SwissProt: O75899 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
    SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5848,Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat

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