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品种反应性 主要应用 宿主 格式 抗体类型 Vrt, B, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-375 Replaces 04-454 品牌系列 Upstate
商名 - Upstate
描述 Anti-Ubiquitin Antibody 产品信息 格式 Purified 控制 - All tissue
演示 Protein A Purified immunoglobulin in PBS, 0.1% sodium azide, and 30% glycerol. 应用 应用 This Anti-Ubiquitin Antibody is validated for use in WB for the detection of Ubiquitin. 主要应用 - Western Blotting
生物信息 免疫原品种 full-length ubiquitin isolated from bovine erythrocytes. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes ubiquitin and ubiquitinylated proteins. 同种型 IgG 品种反应性 VertebratesBovineHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002954.3
Entrez基因汇总 This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. 基因符号 - HUBCEP80
- RPS27A
- CEP80
- ubiquitin
- ubiquitin-CEP80
- UBCEP1
- Ubiquitin.
- UBA52
- UBCEP2
- UBA80
- UBC
- UBB
纯化方法 Protein A purfied UniProt编号 - P62988
UniProt汇总 FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
SIZE: 76 amino acids; 8565 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).产品使用声明 质量保证 routinely evaluated by immunoblot from bovine erythrocytes, and ubiquitylated proteins in acid extracts from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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