merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1999,Anti-Integrin α5β1 Antibody, clone HA5

  • merck millipore,默克密理博,MAB1999,Anti-Integrin α5β1 Antibody, clone HA5

    产品名称：Anti-Integrin α5β1 Antibody, clone HA5
    产品型号：MAB1999
    Anti-Integrin α5β1 Antibody, clone HA5 detects level of Integrin α5β1 & has been published & validated for use in FC & IP.

    merck millipore,默克密理博,MAB1999,Anti-Integrin α5β1 Antibody, clone HA5

  • 产品介绍
  • merck millipore,默克密理博,MAB1999,Anti-Integrin α5β1 Antibody, clone HA5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1999
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α5β1 Antibody, clone HA5
    Alternate Names
    • VLA-5
    产品信息
    格式 Purified
    演示 Purified immunoglobulin from Protein A chromatography. Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl, 0.1% sodium azide.
    应用
    应用 Anti-Integrin α5β1 Antibody, clone HA5 detects level of Integrin α5β1 & has been published & validated for use in FC & IP.
    主要应用
    • Flow Cytometry
    应用说明 Immunoprecipitation of VLA-5 integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB1999.

    Flow cytometry: 10 μg/mL

    Does not detect VLA-5 by Western blot.

    MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 HA5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the fibronectin receptor VLA-5 (alpha-5beta-1) integrin complex.
    同种型 IgG2bκ
    品种反应性 PigHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002205.2
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    基因符号
    • FNRA
    • ITGA5
    • VLA-5
    • CD49e
    • VLA5A
    纯化方法 Protein A purfied
    UniProt编号
    • P08648
    UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1049 amino acids; 114536 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1999,Anti-Integrin α5β1 Antibody, clone HA5

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