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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 04-037 商名 - Upstate
描述 Anti-RalB Antibody, clone 25 Alternate Names - GTP binding protein)
- RAS-like protein B
- v-ral simian leukemia viral oncogene homolog B
- GTP binding protein
- v-ral simian leukemia viral oncogene homolog B (ras<br />related
背景信息 RalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarizatied exocystossis in epithelaial cells (Cascone, 2008). RalB is required for metastatic formation and cell survival by driving exocyst assembly during polarized cell migration (Cascone, 2008). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes 产品信息 格式 Purified 演示 Purified mouse monoclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect RalB using this Anti-RalB Antibody, clone 25 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide of the C-terminus of RalB 表位 C-terminus 克隆 Clone 25 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody is specific for RalB and does not detect RalA. 同种型 IgG1κ 品种反应性 RatHumanMouse Species Reactivity Note Human, Mouse, and Rat. Other species have not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002881.2
Entrez基因汇总 This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. 基因符号 - RALB
纯化方法 Protein G purfied UniProt编号 - P11234
UniProt汇总 SUBUNIT STRUCTURE: Interacts with EXOC8. Interacts with RALBP1 via its effector domain. Ref.6 Ref.7
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family.产品使用声明 质量保证 Evaluated by western blot on HEK293 or NIH/3T3 cell lysates.
Western Blot Analysis:
1:1,000 dilution of this antibody was used to detect RalB in HEK293, NIH/3T3, and rat liver cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
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