merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE215,Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

  • merck millipore,默克密理博,MABE215,Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

    产品名称：Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1
    产品型号：MABE215
    Use Anti-LRH-1 Antibody, clone 1LRH-2E1 (Mouse Monoclonal Antibody) validated in WB, ICC to detect LRH-1 also known as Liver receptor homolog 1.

    merck millipore,默克密理博,MABE215,Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

  • 产品介绍
  • merck millipore,默克密理博,MABE215,Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MABE215
    描述 Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1
    Alternate Names
    • NR5A2
    • Nuclear receptor subfamily 5 group A member 2
    • Liver receptor homolog 1
    • LRH-1
    背景信息 Liver receptor homolog 1 (LRH-1, CPF, FTF, PHR-1, FTF, or hB1F) is an orphan nuclear receptor that is highly expressed in the intestines, pancreas, ovary, and liver. LRH-1 is a constitutively active transcription factor with a complex role in many cellular processes which may include lipid metabolism, cell proliferation, development, reproduction, and immunity. LRH-1 may interact with an array of transcriptional coactivators that modulate its activity, among which are the MBF1, SRC, and PGC-1α proteins. In addition, ERK phosphorylation on Ser-238 and Ser-243 also enhances LRH-1 activity. However, LRH-1 is also negatively regulated by several factors. For instance, corepressors such as SHP, DAX-1, and PROX-1, preclude its binding to DNA; and sumoylation promotes its inactivation and sequestration into nuclear bodies. LRH-1 targets many genes including the CYP7A1 and CYP8B1 genes involved in bile synthesis; and Oct4 required for pluripotency in embryonic stem cells. LRH-1 has been implicated in inflammatory bowel disease, and tumor development in the intestines and pancreas.
    产品信息
    格式 Ascites
    控制
    • Mouse pancreas tissue lysate
    演示 Mouse monoclonal IgG2aλ ascites with 0.05% sodium azide.
    应用
    应用 Use Anti-LRH-1 Antibody, clone 1LRH-2E1 (Mouse Monoclonal Antibody) validated in WB, ICC to detect LRH-1 also known as Liver receptor homolog 1.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: A 1:1,000 dilution from representative lot detected Liver receptor homolog-1 in HepG2 and HeLa cell lysates (M. Oulad, IGBMC, France.).

    Immunocytochemistry Analysis: A representative lot detected Liver receptor homolog-1 in HepG2 and HeLa cells (M. Oulad, IGBMC, France.).
    生物信息
    免疫原品种 Linear peptide corresponding to the mouse Liver receptor homolog-1.
    克隆 1LRH-2E1
    宿主 Mouse
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_109601
    基因符号
    • Lrh1
    • Nr5a2
    纯化方法 Unpurified
    UniProt编号
    • P45448
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse pancreas tissue lysate.

    Western Blot Analysis: A 1:1,000 dilution of this antibody detected Liver receptor homolog-1 in 10 µg of mouse pancrease tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABE215,Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

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