merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1905-I,Anti-Laminin α1/β1 Antibody, clone AL-4

  • merck millipore,默克密理博,MAB1905-I,Anti-Laminin α1/β1 Antibody, clone AL-4

    产品名称：Anti-Laminin α1/β1 Antibody, clone AL-4
    产品型号：MAB1905-I
    Anti-Laminin α1/β1 Antibody, clone AL-4 is an antibody against Laminin α1/β1 for use in Western Blotting, ICC.

    merck millipore,默克密理博,MAB1905-I,Anti-Laminin α1/β1 Antibody, clone AL-4

  • 产品介绍
  • merck millipore,默克密理博,MAB1905-I,Anti-Laminin α1/β1 Antibody, clone AL-4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MICC, WBRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1905-I
    Replaces MAB1905
    描述 Anti-Laminin α1/β1 Antibody, clone AL-4
    Alternate Names
    • Serine/threonine-protein kinase PLK4
    • Laminin subunit beta-1
    • Laminin subunit alpha-1
    • Laminin α1/β1
    背景信息 Laminins are secreted glycoproteins, and are an important structural component of the extracellular matrix. The family of laminins is comprised of multiple isoforms, each formed from the oligomerization of various alpha, beta, and gamma chains. Laminin isoforms are expressed in a tissue-specific pattern, and contain multiple domains, which may include laminin EGF-like domains; laminin G-domains; laminin IV type A domains; and a laminin N-terminal domain. Laminins are capable of self-assembly to form a structural scaffold; they also bind to cell-surface molecules such as dystroglycan and mediate attachment of these molecules to the extracellular matrix. Laminins may also participate in intracellular signaling processes by binding to various integrin receptors. They are involved in cell adhesion, migration, differentiation, neurite outgrowth, and metastasis.
    产品信息
    格式 Purified
    控制
    • Laminin purified protein
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Laminin α1/β1 Antibody, clone AL-4 is an antibody against Laminin α1/β1 for use in Western Blotting, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Laminin isolated from mouse EHS tumor
    克隆 AL-4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 As originally characterized, clone AL-4 reacts with EHS mouse laminin, A chain (laminin α1). The epitope is mapped to the carboxy terminal globular domain on the A chain. Recent work by Scheele, et al. (2006) has further demonstrated that clone AL-4, under reducing conditions, recognized both the 200 kDa β1/γ1 band and the 400 kDa α1 band of mouse EHS laminin. However the affinity for the 400 kDa band was very low. AL-4 also demonstrated strong binding the Laminin β1. By ELISA the epitope for the AL-4 seemed to be located on the Laminin β1 chain, however the clone also recognizes the laminin α1 chain in immunoblots, thus AL-4 seems to show mixed cross reactivity to laminins α1 and β1, with the β1 reactivity being more prominent.
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_032506
    基因符号
    • PLK4
    • Lamb1
    • Lamb-1
    • Lamb1-1
    • LAMA1
    • LAMA
    • PLK-4
    纯化方法 Protein G purified
    UniProt编号
    • P19137
    产品使用声明
    质量保证 Evaluated by Western Blot in Laminin purified protein.

    Western Blot Analysis: 0.25 µg/mL of this antibody detected Laminin α1/β1 in 10 µg of Laminin purified protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1905-I,Anti-Laminin α1/β1 Antibody, clone AL-4

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