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merck millipore,默克密理博,662125,Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem
产品名称：Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem
产品型号：662125
The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Prote More>>
merck millipore,默克密理博,662125,Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₄N₂O₇S 108477-18-5 描述 概述 A cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 = ~ 30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO. 产品目录编号 662125 品牌系列 Calbiochem®
同义词 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303 参考 参考 Fontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.产品信息 CAS号 108477-18-5 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₉H₁₄N₂O₇S 化学配方 C₁₉H₁₄N₂O₇S Molar Mass 414.4 可逆 N 结构配方图像 生物信息 主靶 Ubiquitin isopeptidase activity 主靶IC50 ~ 30 µM against ubiquitin isopeptidase activity; 1.76 and 1.6 µM for the induction of caspase activation and apoptosis in E1A and E1A/C9DN cells, respectively 纯度 ≥97% by Elemental analysis 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Unstable in DMSO; reconstitute just prior to use. 包装信息 惰性气体下包装 Packaged under inert gas
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