merck millipore,默克密理博,554718,REV-ERBα Antagonist, SR8278

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Merck Millipore 默克密理愽

merck millipore,默克密理博,554718,REV-ERBα Antagonist, SR8278 - Calbiochem

经验配方
C₁₈H₁₉NO₃S₂₃

描述
概述	A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
产品目录编号	554718
品牌系列	Calbiochem®
同义词	SR8278 SR 8278

参考
参考	Kojetin, D., et al. 2010, Chem Bio in press

生物信息
纯度	>95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,554718,REV-ERBα Antagonist, SR8278 - Calbiochem

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