merck millipore,默克密理愽
  • merck millipore,默克密理博,GF029,Brain Derived Neurotrophic Factor, recombinant

  • merck millipore,默克密理博,GF029,Brain Derived Neurotrophic Factor, recombinant

    产品名称：Brain Derived Neurotrophic Factor, recombinant
    产品型号：GF029
    The recombinant BDNF protein is a potent neurotrophic factor which supports the growth & survivability of nerve and/or glial cells.

    merck millipore,默克密理博,GF029,Brain Derived Neurotrophic Factor, recombinant

  • 产品介绍
  • merck millipore,默克密理博,GF029,Brain Derived Neurotrophic Factor, recombinant

    重要规格表

    品种 来源 纯度
    HumanE. coliGreater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of BDNF.
    描述
    产品目录编号 GF029
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Brain Derived Neurotrophic Factor, recombinant
    概述 BDNF is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human BDNF is a 27.0 kDa dimer, formed by two identical 119 amino acid subunits, which is held together by strong hydrophobic interactions.
    Alternate Names
    • BDNF
    产品信息
    演示 Sterile filtered, lyophilized with no additives.
    应用
    应用 The recombinant BDNF protein is a potent neurotrophic factor which supports the growth & survivability of nerve and/or glial cells.
    应用说明 Concentration range for most in vitro applications is 0.5 to 100 ng/mL. Responding cells are (partial list): Nerve, glial cells.
    生物信息
    纯度 Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of BDNF.
    来源 E. coli
    品种 Human
    特异活性 Chemicon's human BDNF is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cultures was found to be 25-50 ng/mL. The ED50 as determined by its availability to stimulate chick E8 neurite outgrowth was found to be 0.1-1.0 ng/mL
    Entrez基因编号
    • NM_170735.4
    • NM_001709.3
    • NM_170731.3
    • NM_170732.3
    • NM_170733.2
    • NM_170734.2
    Entrez基因汇总 The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
    基因符号
    • MGC34632
    • BDNF
    • Abrineurin
    • neurotrophin
    UniProt编号
    • P23560
    UniProt汇总 FUNCTION: SwissProt: P23560 # Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
    SIZE: 247 amino acids; 27818 Da
    SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
    SUBCELLULAR LOCATION: Secreted.
    PTM: The propeptide is N-glycosylated and glycosulfated. & Converted into mature BDNF by plasmin (PLG) (By similarity).
    DISEASE: SwissProt: P23560 # Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
    SIMILARITY: SwissProt: P23560 ## Belongs to the NGF-beta family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into water or other buffered solutions. Reconstituted BDNF should be stored in undiluted aliquots at -20°C for up to six months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,GF029,Brain Derived Neurotrophic Factor, recombinant

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